Plasma C1qTNF-Related Protein-3 (CTRP-3)‎ and High-Mobility Group Box-1 (HMGB-1)‎ Concentrations in Subjects with Prediabetes and Type 2 Diabetes

Abstract EN

Aims.

To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM).

Methods.

224 eligible participants were included.

The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured.

All participants were divided into three groups: normal glucose tolerance (NGT, n = 62 ), pre-DM ( n = 111 ), and nT2DM group ( n = 56 ).

Results.

Plasma CTRP-3 concentrations were significantly lower in subjects with pre-DM and nT2DM than that of the NGT group, while plasma HMGB-1 levels were higher in pre-DM and nT2DM group compared with the NGT group ( P < 0.05 ).

A multiple linear regression analysis showed both plasma CTRP-3 and HMGB-1 concentrations were independently associated with homeostasis model assessment for insulin resistance (HOMA-IR) and interleukin-6 (IL-6) ( P < 0.05 for all).

Further multiple logistical regression analyses revealed that both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-DM and nT2DM after adjusting for several confounders ( P < 0.0 01 for all).

Conclusions.

Circulating CTRP-3 and HMGB-1 concentrations might be promising biomarkers to predict prediabetes and type 2 diabetes.