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Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model
Joint Authors
Zhou, Mengtao
Xu, Xiaole
Chen, Bi-Cheng
He, Yunqiang
Xu, Ziqiang
Wang, Silu
Cai, Yong
Fu, Hongxing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Revascularization of aortorenal bypass is a preferred technique for renal artery stenosis (RAS) in diabetic nephropathy (DN) patients.
Restenosis of graft vessels also should be considered in patients lacking good control of blood glucose.
In this study, we explored a combined strategy to prevent the recurrence of RAS in the DN rat model.
Methods.
A model of DN was established by intraperitoneal injection of streptozotocin.
Rats were divided into 4 groups: SR group, MIT group, Com group, and the untreated group.
The levels of blood glucose and urine protein were measured, and changes in renal pathology were observed.
The expression of monocyte chemoattractant protein-1 (MCP-1) in graft vessels was assessed by immunohistochemical staining.
Histopathological staining was performed to assess the pathological changes of glomeruli and tubules.
Results.
The levels of urine protein and the expression of MCP-1 in graft vessels were decreased after islet transplantation.
The injury of glomerular basement membrane and podocytes was significantly ameliorated.
Conclusions.
The combined strategy of revascularization and microencapsulated islet transplantation had multiple protective effects on diabetic nephropathy, including preventing atherosclerosis in the graft vessels and alleviating injury to the glomerular filtration barrier.
This combined strategy may be helpful for DN patients with RAS.
American Psychological Association (APA)
He, Yunqiang& Xu, Ziqiang& Fu, Hongxing& Xu, Xiaole& Wang, Silu& Chen, Bi-Cheng…[et al.]. 2016. Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108337
Modern Language Association (MLA)
He, Yunqiang…[et al.]. Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108337
American Medical Association (AMA)
He, Yunqiang& Xu, Ziqiang& Fu, Hongxing& Xu, Xiaole& Wang, Silu& Chen, Bi-Cheng…[et al.]. Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108337