Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms
Joint Authors
Quan, Jinxing
Zhang, Qi
Zhao, Juan
Liu, Jing
Tian, Liming
Huang, Wenhui
Wang, Jinyang
Xu, Yanjia
Wang, Yunfang
Niu, Ruilan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We found in the present study that treatment with ox-LDL decreased the cell viability and the content of nitric oxide (NO) and the activity of nitric oxide synthase (NOS) as well as eNOS mRNA expression, while increasing the mRNA expression and content of endothelin-1 (ET-1) in human umbilical vein endothelial cells (HUVECs).
However, endomorphins EM1/EM2 increased the cell viability and the content of NO and the activity of NOS as well as eNOS mRNA expression, while decreasing the mRNA expression and content of ET-1 compared with ox-LDL alone.
Meanwhile, the expressions of JNK and p-JNK were enhanced by ox-LDL while being suppressed by EM1/EM2.
The results suggested that EM1 and EM2 can correct the endothelial cell dysfunction induced by ox-LDL and the protective effect may be achieved by affecting the JNK pathway.
American Psychological Association (APA)
Zhao, Juan& Zhang, Qi& Liu, Jing& Tian, Liming& Huang, Wenhui& Quan, Jinxing…[et al.]. 2016. Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108340
Modern Language Association (MLA)
Zhao, Juan…[et al.]. Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108340
American Medical Association (AMA)
Zhao, Juan& Zhang, Qi& Liu, Jing& Tian, Liming& Huang, Wenhui& Quan, Jinxing…[et al.]. Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108340