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Neutrophil Functions in Periodontal Homeostasis
Joint Authors
Rosales, C.
Uribe-Querol, Eileen
Cortés-Vieyra, Ricarda
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral tissues are constantly exposed to damage from the mechanical effort of eating and to microorganisms, mostly bacteria.
In healthy gingiva tissue remodeling and a balance between bacteria and innate immune cells are maintained.
However, excess of bacteria biofilm (plaque) creates an inflammation state that recruits more immune cells, mainly neutrophils to the gingiva.
Neutrophils create a barrier for bacteria to reach inside tissues.
When neutrophils are insufficient, bacteria thrive causing more inflammation that has been associated with systemic effects on other conditions such as atherosclerosis, diabetes, and cancer.
But paradoxically when neutrophils persist, they can also promote a chronic inflammatory state that leads to periodontitis, a condition that leads to damage of the bone-supporting tissues.
In periodontitis, bone loss is a serious complication.
How a neutrophil balance is needed for maintaining healthy oral tissues is the focus of this review.
We present recent evidence on how alterations in neutrophil number and function can lead to inflammatory bone loss, and how some oral bacteria signal neutrophils to block their antimicrobial functions and promote an inflammatory state.
Also, based on this new information, novel therapeutic approaches are discussed.
American Psychological Association (APA)
Cortés-Vieyra, Ricarda& Rosales, C.& Uribe-Querol, Eileen. 2016. Neutrophil Functions in Periodontal Homeostasis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108708
Modern Language Association (MLA)
Cortés-Vieyra, Ricarda…[et al.]. Neutrophil Functions in Periodontal Homeostasis. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108708
American Medical Association (AMA)
Cortés-Vieyra, Ricarda& Rosales, C.& Uribe-Querol, Eileen. Neutrophil Functions in Periodontal Homeostasis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108708