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State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization
Joint Authors
Alicino, Cristiano
Orsi, Andrea
Sticchi, Laura
Ansaldi, Filippo
Icardi, Giancarlo
Trucchi, Cecilia
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Hepatitis C virus (HCV) still represents a major public health threat, with a dramatic burden from both epidemiological and clinical points of view.
New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the issues related to the interferon-based therapies.
However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide.
Moreover, these treatments remain poorly accessible, particularly in low-income countries.
Finally, effective screening strategy is crucial to early identifying and treating all HCV chronically infected patients.
For all these reasons, even though new drugs may contribute to impacting HCV spread worldwide a preventive HCV vaccine remains a cornerstone in the road to significantly reduce the HCV spread globally, with the ultimate goal of its eradication.
Advances in molecular vaccinology, together with a strong financial, political, and societal support, will enable reaching this fundamental success in the coming years.
In this comprehensive review, the state of the art about these major topics in the fight against HCV and the future of research in these fields are discussed.
American Psychological Association (APA)
Trucchi, Cecilia& Orsi, Andrea& Alicino, Cristiano& Sticchi, Laura& Icardi, Giancarlo& Ansaldi, Filippo. 2016. State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108710
Modern Language Association (MLA)
Trucchi, Cecilia…[et al.]. State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization. Journal of Immunology Research No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1108710
American Medical Association (AMA)
Trucchi, Cecilia& Orsi, Andrea& Alicino, Cristiano& Sticchi, Laura& Icardi, Giancarlo& Ansaldi, Filippo. State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108710