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Adjuvants: Classification, Modus Operandi, and Licensing
Joint Authors
Rosa, Daniela Santoro
Apostólico, Juliana de Souza
Lunardelli, Victória Alves Santos
Coirada, Fernanda Caroline
Boscardin, Silvia Beatriz
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of adjuvants is strongly recommended.
Since their discovery in the beginning of the 20th century, adjuvants have been used to improve immune responses that ultimately lead to protection against disease.
The choice of the adjuvant is of utmost importance as it can stimulate protective immunity.
Their mechanisms of action have now been revealed.
Our increasing understanding of the immune system, and of correlates of protection, is helping in the development of new vaccine formulations for global infections.
Nevertheless, few adjuvants are licensed for human vaccines and several formulations are now being evaluated in clinical trials.
In this review, we briefly describe the most well known adjuvants used in experimental and clinical settings based on their main mechanisms of action and also highlight the requirements for licensing new vaccine formulations.
American Psychological Association (APA)
Apostólico, Juliana de Souza& Lunardelli, Victória Alves Santos& Coirada, Fernanda Caroline& Boscardin, Silvia Beatriz& Rosa, Daniela Santoro. 2016. Adjuvants: Classification, Modus Operandi, and Licensing. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108713
Modern Language Association (MLA)
Apostólico, Juliana de Souza…[et al.]. Adjuvants: Classification, Modus Operandi, and Licensing. Journal of Immunology Research No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1108713
American Medical Association (AMA)
Apostólico, Juliana de Souza& Lunardelli, Victória Alves Santos& Coirada, Fernanda Caroline& Boscardin, Silvia Beatriz& Rosa, Daniela Santoro. Adjuvants: Classification, Modus Operandi, and Licensing. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108713