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How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
Joint Authors
Sheikh, Nadeem
Khawar, Muhammad Babar
Azam, Fareeha
Abdul Mujeeb, Khawaja
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine family.
It is the only interleukin produced by immune cells but does not target immune system components.
IL-22 is mainly produced by dendritic cells (DCs) and TH17, TH22, NK, and NKT cells and targets a number of body tissues including liver, pancreas, and other epithelial tissues.
It provokes a series of downstream signaling pathways upon binding with IL-22R complex which protects liver damage through STAT3 activation.
IL-22BP is an inhibitor of IL-22 which has 20–1000x more affinity to bind with IL-22 compared to IL-22R1 that inhibits IL-22 activity.
Its level was found to be positively correlated with the severity of liver damage and fibrosis.
So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications.
American Psychological Association (APA)
Khawar, Muhammad Babar& Azam, Fareeha& Sheikh, Nadeem& Abdul Mujeeb, Khawaja. 2016. How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108730
Modern Language Association (MLA)
Khawar, Muhammad Babar…[et al.]. How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108730
American Medical Association (AMA)
Khawar, Muhammad Babar& Azam, Fareeha& Sheikh, Nadeem& Abdul Mujeeb, Khawaja. How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108730