Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience
Joint Authors
Zhu, Lan
Fu, Cheng
Lin, Kailin
Wang, Zhiqiang
Guo, Hui
Chen, Song
Lin, Zhengbin
Chen, Zhishui
Chen, Gang
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It has been reported that kidney retransplant patients had high rates of early acute rejection due to previous sensitization.
In addition to the acute antibody-mediated rejection (ABMR) that has received widespread attention, the early acute T-cell-mediated rejection (TCMR) may be another important issue in renal retransplantation.
In the current single-center retrospective study, we included 33 retransplant patients and 90 first transplant patients with similar protocols of induction and maintenance therapy.
Analysis focused particularly on the incidence and patterns of early acute rejection episodes, as well as one-year graft and patient survival.
Excellent short-term clinical outcomes were obtained in both groups, with one-year graft and patient survival rates of 93.9%/100% in the retransplant group and 92.2%/95.6% in the first transplant group.
Impressively, with our strict immunological selection and desensitization criteria, the retransplant patients had a very low incidence of early acute ABMR (6.1%), which was similar to that in the first transplant patients (4.4%).
However, a much higher rate of early acute TCMR was observed in the retransplant group than in the first transplant group (30.3% versus 5.6%, P<0.001).
Acute TCMR that develops early after retransplantation should be monitored in order to obtain better transplant outcomes.
American Psychological Association (APA)
Zhu, Lan& Fu, Cheng& Lin, Kailin& Wang, Zhiqiang& Guo, Hui& Chen, Song…[et al.]. 2016. Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108741
Modern Language Association (MLA)
Zhu, Lan…[et al.]. Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108741
American Medical Association (AMA)
Zhu, Lan& Fu, Cheng& Lin, Kailin& Wang, Zhiqiang& Guo, Hui& Chen, Song…[et al.]. Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108741