Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus
Joint Authors
Xu, Jian
Cheng, Yuqi
Lai, Aiyun
Bai, Ru
Liu, Shuang
Li, Shu
Lu, Zhaoping
Chen, Fan
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team.
To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis.
Interestingly, the results suggest that the frequencies of SS genotype and S allele in SLE patients with positive anti-Sm antibody and anti-U1RNP antibody were both significantly higher than the other genotypes and alleles.
However, the frequencies of 5-HTTLPR genotypes and alleles were of no significant difference between SLE patients and HCs.
This suggested that 5-HTTLPR was not a high-risk susceptible gene in SLE but might relate to SLE by affecting production of some autoantibodies, especially anti-Sm and anti-U1RNP antibody.
American Psychological Association (APA)
Li, Shu& Liu, Shuang& Chen, Fan& Cheng, Yuqi& Bai, Ru& Lai, Aiyun…[et al.]. 2016. Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108752
Modern Language Association (MLA)
Li, Shu…[et al.]. Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108752
American Medical Association (AMA)
Li, Shu& Liu, Shuang& Chen, Fan& Cheng, Yuqi& Bai, Ru& Lai, Aiyun…[et al.]. Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108752