The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis
Joint Authors
Silosi, Isabela
Cojocaru, Manole
Silosi, Isabela
Petrescu, Florin
Biciusca, Viorel
Pădureanu, Vlad
Bogdan, Maria
Badea, Ramona Georgiana
Avramescu, Carmen
Petrescu, Ileana Octavia
Siloşi, Cristian A.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of the utility of IL-13 and -17 concentration measurements as markers of disease activity.
Materials and Methods.
Serum samples were collected from 30 patients and from 28 controls and analysed parameters.
Results.
The serum concentrations of IL-13, IL-17, anti-CCP, and IgM-RF were statistically significantly higher in patients with eRA, compared to the controls.
IL-13 concentrations in the severe and moderate groups with eRA were statistically higher than in the mild and control groups.
Also, in the case of IL-17, serum concentrations increased proportionally with the disease activity of eRA.
We observe that concentrations of IL-13 and -17 did not correlate with autoantibodies.
IL-17 concentration significantly positively correlated with CRP, while IL-13 concentration significantly negatively correlated with CRP.
Disease activity score, DAS28, was strongly positively correlated with levels of ESR and weakly positively correlated with concentrations of anti-RA33 autoantibodies.
IL-13 has a higher diagnostic utility than IL-17, CRP, ESR, IgM-RF, and anti-CCP as markers of disease activity.
Conclusions.
The presence of higher IL-13 and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA.
IL-13 and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP.
American Psychological Association (APA)
Silosi, Isabela& Silosi, Isabela& Cojocaru, Manole& Biciusca, Viorel& Pădureanu, Vlad& Bogdan, Maria…[et al.]. 2016. The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108755
Modern Language Association (MLA)
Silosi, Isabela…[et al.]. The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108755
American Medical Association (AMA)
Silosi, Isabela& Silosi, Isabela& Cojocaru, Manole& Biciusca, Viorel& Pădureanu, Vlad& Bogdan, Maria…[et al.]. The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108755