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Actions of Thyroid Hormone Analogues on Chemokines
Joint Authors
Davis, Paul J.
Lin, Hung-Yun
Glinsky, Gennadi V.
Mousa, Shaker A.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3′-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4.
Tetrac inhibits the binding of T4 and T3 to the integrin.
Fractalkine (CX3CL1) is a chemokine relevant to inflammatory processes in the CNS that are microglia-dependent but also important to normal brain development.
Expression of the CX3CL1 gene is downregulated by tetrac, suggesting that T4 and T3 may stimulate fractalkine expression.
Independently of its specific receptor (CX3CR1), fractalkine binds to αvβ3 at a site proximal to the thyroid hormone-tetrac receptor and changes the physical state of the integrin.
Tetrac also affects expression of the genes for other CNS-relevant chemokines, including CCL20, CCL26, CXCL2, CXCL3, and CXCL10.
The chemokine products of these genes are important to vascularity of the brain, particularly of the choroid plexus, to inflammatory processes in the CNS and, in certain cases, to neuroprotection.
Thyroid hormones are known to contribute to regulation of each of these CNS functions.
We propose that actions of thyroid hormone and hormone analogues on chemokine gene expression contribute to regulation of inflammatory processes in brain and of brain blood vessel formation and maintenance.
American Psychological Association (APA)
Davis, Paul J.& Glinsky, Gennadi V.& Lin, Hung-Yun& Mousa, Shaker A.. 2016. Actions of Thyroid Hormone Analogues on Chemokines. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108757
Modern Language Association (MLA)
Davis, Paul J.…[et al.]. Actions of Thyroid Hormone Analogues on Chemokines. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108757
American Medical Association (AMA)
Davis, Paul J.& Glinsky, Gennadi V.& Lin, Hung-Yun& Mousa, Shaker A.. Actions of Thyroid Hormone Analogues on Chemokines. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108757