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Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking
Joint Authors
Blanco-Favela, Francisco
Gorocica-Rosete, Patricia
Pizaña-Venegas, Alberto
Flores-Fernández, Rocio
Chávez-Rueda, Adriana Karina
Chávez-Sánchez, Luis
Fuentes-Pananá, Ezequiel M.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prolactin has an immunomodulatory effect and has been associated with B-cell-triggered autoimmune diseases, such as systemic lupus erythematosus (SLE).
In mice that develop SLE, the PRL receptor is expressed in early bone marrow B-cells, and increased levels of PRL hasten disease manifestations, which are correlated with a reduction in the absolute number of immature B-cells.
The aim of this work was to determine the effect of PRL in an in vitro system of B-cell tolerance using WEHI-231 cells and immature B-cells from lupus prone MRL/lpr mice.
WEHI-231 cells express the long isoform of the PRL receptor, and PRL rescued the cells from cell death by decreasing the apoptosis induced by the cross-linking of the B-cell antigen receptor (BCR) as measured by Annexin V and active caspase-3.
This decrease in apoptosis may have been due to the PRL and receptor interaction, which increased the relative expression of antiapoptotic Bcl-xL and decreased the relative expression of proapoptotic Bad.
In immature B-cells from MRL/lpr mice, PRL increased the viability and decreased the apoptosis induced by the cross-linking of BCR, which may favor the maturation of self-reactive B-cells and contribute to the onset of disease.
American Psychological Association (APA)
Flores-Fernández, Rocio& Blanco-Favela, Francisco& Fuentes-Pananá, Ezequiel M.& Chávez-Sánchez, Luis& Gorocica-Rosete, Patricia& Pizaña-Venegas, Alberto…[et al.]. 2016. Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108759
Modern Language Association (MLA)
Flores-Fernández, Rocio…[et al.]. Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108759
American Medical Association (AMA)
Flores-Fernández, Rocio& Blanco-Favela, Francisco& Fuentes-Pananá, Ezequiel M.& Chávez-Sánchez, Luis& Gorocica-Rosete, Patricia& Pizaña-Venegas, Alberto…[et al.]. Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108759