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The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers
Joint Authors
Barjaktarevic, Igor Z.
Crystal, Ronald G.
Kaner, Robert J.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Rationale.
Matrix metalloproteinase-9 (MMP-9) expression is upregulated in alveolar macrophages (AM) of HIV1+ smokers who develop emphysema.
Knowing that lung epithelial lining fluid (ELF) of HIV1+ smokers contains increased levels of inflammatory cytokines compared to HIV1− smokers, we hypothesized that upregulation of lung cytokines in HIV1+ smokers may be functionally related to increased MMP-9 expression.
Methods.
Cytokine arrays evaluated cytokine protein levels in ELF obtained from 5 groups of individuals: HIV1− healthy nonsmokers, HIV1− healthy smokers, HIV1− smokers with low diffusing capacity ( D L C O ), HIV1+ nonsmokers, and HIV1+ smokers with low D L C O .
Results.
Increased levels of the Th17 related cytokine IL-23 were found in HIV1− smokers with low D L C O and HIV1+ smokers and nonsmokers.
Relative IL-23 gene expression was increased in AM of HIV1+ individuals, with greater expression in AM of HIV1+ smokers with low D L C O .
Infection with HIV1 in vitro induced IL-23 expression in normal AM.
IL-23 stimulation of AM/lymphocyte cocultures in vitro induced upregulation of MMP-9.
Lung T lymphocytes express receptor IL-23R and interact with AM in order to upregulate MMP-9.
Conclusion.
This mechanism may contribute to the increased tissue destruction in the lungs of HIV1+ smokers and suggests that Th17 related inflammation may play a role.
American Psychological Association (APA)
Barjaktarevic, Igor Z.& Crystal, Ronald G.& Kaner, Robert J.. 2016. The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108761
Modern Language Association (MLA)
Barjaktarevic, Igor Z.…[et al.]. The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108761
American Medical Association (AMA)
Barjaktarevic, Igor Z.& Crystal, Ronald G.& Kaner, Robert J.. The Role of Interleukin-23 in the Early Development of Emphysema in HIV1+ Smokers. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108761