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The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells
Joint Authors
Espinosa-Cueto, Patricia
Magallanes-Puebla, Alejandro
García, Teresa
Mancilla, Raúl
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Upon Mycobacterium tuberculosis infection, macrophages may undergo apoptosis, which has been considered an innate immune response.
The pathways underlying the removal of dead cells in homeostatic apoptosis have been extensively studied, but little is known regarding how cells that undergo apoptotic death during mycobacterial infection are removed.
This study shows that macrophages induced to undergo apoptosis with mycobacteria cell wall proteins are engulfed by J-774A.1 monocytic cells through the mannose receptor.
This demonstration was achieved through assays in which phagocytosis was inhibited with a blocking anti-mannose receptor antibody and with mannose receptor competitor sugars.
Moreover, elimination of the mannose receptor by a specific siRNA significantly diminished the expression of the mannose receptor and the phagocytosis of apoptotic cells.
As shown by immunofluorescence, engulfed apoptotic bodies are initially located in Rab5-positive phagosomes, which mature to express the phagolysosome marker LAMP1.
The phagocytosis of dead cells triggered an anti-inflammatory response with the production of TGF-β and IL-10 but not of the proinflammatory cytokines IL-12 and TNF-α.
This study documents the previously unreported participation of the mannose receptor in the removal of apoptotic cells in the setting of tuberculosis (TB) infection.
The results challenge the idea that apoptotic cell phagocytosis in TB has an immunogenic effect.
American Psychological Association (APA)
García, Teresa& Espinosa-Cueto, Patricia& Magallanes-Puebla, Alejandro& Mancilla, Raúl. 2016. The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108766
Modern Language Association (MLA)
García, Teresa…[et al.]. The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108766
American Medical Association (AMA)
García, Teresa& Espinosa-Cueto, Patricia& Magallanes-Puebla, Alejandro& Mancilla, Raúl. The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108766