Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects
Joint Authors
Han, Wei-Dong
Guo, Yelei
Wang, Yao
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years.
The few published clinical studies of CART cells in solid tumors have addressed safety and feasibility, but the clinical outcome data are limited.
Although antitumor effects were confirmed in vitro and in animal models, CART-cell-based therapy still faces several challenges when directed towards solid tumors, and it has been difficult to achieve the desired outcomes in clinical practice.
Many studies have struggled to improve the clinical responses to and benefits of CART-cell treatment of solid tumors.
In this review, the status quo of CART cells and their clinical applications for solid tumors will be summarized first.
Importantly, we will suggest improvements that could increase the therapeutic effectiveness of CART cells for solid tumors and their future clinical applications.
These interventions will make treatment with CART cells an effective and routine therapy for solid tumors.
American Psychological Association (APA)
Guo, Yelei& Wang, Yao& Han, Wei-Dong. 2016. Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108767
Modern Language Association (MLA)
Guo, Yelei…[et al.]. Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108767
American Medical Association (AMA)
Guo, Yelei& Wang, Yao& Han, Wei-Dong. Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108767