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Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection
Joint Authors
Fainardi, Enrico
Rizzo, Roberta
Gentili, Valentina
Capretti, Maria Grazia
Lazzarotto, Tiziana
Gabrielli, Liliana
Bortolotti, Daria
Piccirilli, Giulia
Chiereghin, Angela
Pavia, Claudia
Bolzani, Silvia
Guerra, Brunella
Simonazzi, Giuliana
Cervi, Francesca
Luca, Dario Di
Landini, Maria Paola
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class I antigen that is expressed during pregnancy contributing to maternal-fetal tolerance.
HLA-G can be expressed as membrane-bound and soluble forms.
HLA-G expression increases strongly during viral infections such as congenital human cytomegalovirus (HCMV) infections, with functional consequences in immunoregulation.
In this work we investigated the expression of soluble (s)HLA-G and beta-2 microglobulin (component of HLA) molecules in correlation with the risk of transmission and severity of congenital HCMV infection.
We analyzed 182 blood samples from 130 pregnant women and 52 nonpregnant women and 56 amniotic fluid samples from women experiencing primary HCMV infection.
The median levels of sHLA-G in maternal serum of women with primary HCMV infection were higher in comparison with nonprimary and uninfected pregnant women ( p < 0.001 ).
AF from HCMV symptomatic fetuses presented higher sHLA-G levels in comparison with infected asymptomatic fetuses ( p < 0.001 ), presence of HLA-G free-heavy chain, and a concentration gradient from amniotic fluid to maternal blood.
No significant statistical difference of beta-2 microglobulin median levels was observed between all different groups.
Our results suggest the determination of sHLA-G molecules in both maternal blood and amniotic fluid as a promising biomarker of diagnosis of maternal HCMV primary infection and fetal HCMV disease.
American Psychological Association (APA)
Rizzo, Roberta& Gabrielli, Liliana& Bortolotti, Daria& Gentili, Valentina& Piccirilli, Giulia& Chiereghin, Angela…[et al.]. 2016. Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108768
Modern Language Association (MLA)
Rizzo, Roberta…[et al.]. Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108768
American Medical Association (AMA)
Rizzo, Roberta& Gabrielli, Liliana& Bortolotti, Daria& Gentili, Valentina& Piccirilli, Giulia& Chiereghin, Angela…[et al.]. Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108768