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Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
Joint Authors
Feijó, Daniel
Tibúrcio, Rafael
Ampuero, Mariana
Tavares, Natalia
Brodskyn, Cláudia
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Leishmaniasis is a group of neglected diseases whose clinical manifestations depend on factors from the host and the pathogen.
It is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus.
Cutaneous Leishmaniasis (CL) is the most frequent form of this disease transmitted by the bite of an infected sandfly into the host skin.
The parasites can be uptook and/or recognized by macrophages, neutrophils, and/or dendritic cells (DCs).
Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites.
However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL.
In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection.
The complexity of these interactions profoundly affects the adaptive immune response and, consequently, the disease outcome, especially from Leishmania species of the New World.
American Psychological Association (APA)
Feijó, Daniel& Tibúrcio, Rafael& Ampuero, Mariana& Brodskyn, Cláudia& Tavares, Natalia. 2016. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108770
Modern Language Association (MLA)
Feijó, Daniel…[et al.]. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108770
American Medical Association (AMA)
Feijó, Daniel& Tibúrcio, Rafael& Ampuero, Mariana& Brodskyn, Cláudia& Tavares, Natalia. Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108770