Gq-Coupled Receptors in Autoimmunity
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Heterotrimeric G proteins can be divided into Gi, Gs, Gq/11, and G12/13 subfamilies according to their α subunits.
The main function of G proteins is transducing signals from G protein coupled receptors (GPCRs), a family of seven transmembrane receptors.
In recent years, studies have demonstrated that GPCRs interact with Gq, a member of the Gq/11 subfamily of G proteins.
This interaction facilitates the vital role of this family of proteins in immune regulation and autoimmunity, particularly for Gαq, which is considered the functional α subunit of Gq protein.
Therefore, understanding the mechanisms through which Gq-coupled receptors control autoreactive lymphocytes is critical and may provide insights into the treatment of autoimmune disorders.
In this review, we summarize recent advances in studies of the role of Gq-coupled receptors in autoimmunity, with a focus on their pathologic role and downstream signaling.
American Psychological Association (APA)
Zhang, Lu& Shi, Guixiu. 2016. Gq-Coupled Receptors in Autoimmunity. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108771
Modern Language Association (MLA)
Zhang, Lu& Shi, Guixiu. Gq-Coupled Receptors in Autoimmunity. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108771
American Medical Association (AMA)
Zhang, Lu& Shi, Guixiu. Gq-Coupled Receptors in Autoimmunity. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108771