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Yeast Surface-Displayed H5N1 Avian Influenza Vaccines
Joint Authors
Lei, Han
Jin, Sha
Karlsson, Erik
Schultz-Cherry, Stacey
Ye, Kaiming
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Highly pathogenic H5N1 avian influenza viruses pose a pandemic threat to human health.
A rapid vaccine production against fast outbreak is desired.
We report, herein, a paradigm-shift influenza vaccine technology by presenting H5N1 hemagglutinin (HA) to the surface of yeast.
We demonstrated, for the first time, that the HA surface-presented yeast can be used as influenza vaccines to elicit both humoral and cell-mediated immunity in mice.
The HI titer of antisera reached up to 128 in vaccinated mice.
A high level of H5N1 HA-specific IgG1 and IgG2a antibody production was detected after boost immunization.
Furthermore, we demonstrated that the yeast surface-displayed HA preserves its antigenic sites.
It preferentially binds to both avian- and human-type receptors.
In addition, the vaccine exhibited high cross-reactivity to both homologous and heterologous H5N1 viruses.
A high level production of anti-HA antibodies was detected in the mice five months after vaccination.
Finally, our animal experimental results indicated that the yeast vaccine offered complete protection of mice from lethal H5N1 virus challenge.
No severe side effect of yeast vaccines was noted in animal studies.
This new technology allows for rapid and large-scale production of influenza vaccines for prepandemic preparation.
American Psychological Association (APA)
Lei, Han& Jin, Sha& Karlsson, Erik& Schultz-Cherry, Stacey& Ye, Kaiming. 2016. Yeast Surface-Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108779
Modern Language Association (MLA)
Lei, Han…[et al.]. Yeast Surface-Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108779
American Medical Association (AMA)
Lei, Han& Jin, Sha& Karlsson, Erik& Schultz-Cherry, Stacey& Ye, Kaiming. Yeast Surface-Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108779