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Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus
Joint Authors
Guerra-de Blas, Paola del Carmen
Villaseñor-Talavera, Yael Sebastián
Cruz-González, Daniela de Jesús
Doníz-Padilla, Lesly
Monsiváis-Urenda, Adriana
González-Amaro, Roberto
Abud-Mendoza, Carlos
Baranda, Lourdes
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dendritic cells (DC) play an important role in the development and maintenance of immune tolerance.
Although the inhibitory receptor ILT4/LILRB2 has been related with the tolerogenic phenotype of DC, the possible role of this receptor in the breakdown of DC tolerogenic function in systemic lupus erythematosus (SLE) has not been elucidated.
In this study, we analyzed the expression and function of the inhibitory receptor ILT4 in DC from SLE patients.
We found that the percentage of ILT4 positive plasmacytoid DC and myeloid DC is significantly diminished in SLE patients.
Interestingly, ligation of ILT4 did not affect the maturation or immunogenic capability of DC in healthy controls.
In contrast, in SLE patients we observed an inhibitory effect of ILT4 on the immunogenic capability of DC.
ILT4 was shown not to have a crucial role in regulating the maturation and function of DC from healthy controls but is partially involved in the maturation process and immunogenic capability of DC from SLE patients, suggesting that other inhibitory receptors, involved in the regulation of DC tolerogenic function, may be impaired in this autoimmune disease.
American Psychological Association (APA)
Guerra-de Blas, Paola del Carmen& Villaseñor-Talavera, Yael Sebastián& Cruz-González, Daniela de Jesús& Baranda, Lourdes& Doníz-Padilla, Lesly& Abud-Mendoza, Carlos…[et al.]. 2016. Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108781
Modern Language Association (MLA)
Guerra-de Blas, Paola del Carmen…[et al.]. Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108781
American Medical Association (AMA)
Guerra-de Blas, Paola del Carmen& Villaseñor-Talavera, Yael Sebastián& Cruz-González, Daniela de Jesús& Baranda, Lourdes& Doníz-Padilla, Lesly& Abud-Mendoza, Carlos…[et al.]. Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108781