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A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?
Joint Authors
Kim, Jung Eun
Sohn, Ki Min
Woo, Young Jun
Jeong, Kwan Ho
Kim, Miri
Lee, Jeong Deuk
Lee, Jun Young
Park, Hyun Jeong
Kim, Gyong Moon
Park, Chul Jong
Yu, Dong Soo
Kang, Hoon
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The clinical and histopathologic classification of anetoderma are not well characterized.
Objective.
We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings.
Methods.
We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2.
Results.
Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13).
MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05).
MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue.
TIMP-1 was highly expressed in anetoderma lesions and controls.
TIMP-2 expression was variable.
Conclusions.
Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.
American Psychological Association (APA)
Kim, Jung Eun& Sohn, Ki Min& Woo, Young Jun& Jeong, Kwan Ho& Kim, Miri& Lee, Jeong Deuk…[et al.]. 2016. A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108784
Modern Language Association (MLA)
Kim, Jung Eun…[et al.]. A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108784
American Medical Association (AMA)
Kim, Jung Eun& Sohn, Ki Min& Woo, Young Jun& Jeong, Kwan Ho& Kim, Miri& Lee, Jeong Deuk…[et al.]. A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108784