Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling
Joint Authors
Huang, Chi-Ying F.
Chuang, Tsung-Hsien
Yeh, Da-Wei
Huang, Li-Rung
Chen, Ya-Wen
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cancer stem cells (CSCs) are a small population of cancer cells that exhibit stemness.
These cells contribute to cancer metastasis, treatment resistance, and relapse following therapy; therefore, they may cause malignancy and reduce the success of cancer treatment.
Nuclear factor kappa B- (NF-κB-) mediated inflammatory responses increase stemness in cancer cells, and CSCs constitutively exhibit higher NF-κB activation, which in turn increases their stemness.
These opposite effects form a positive feedback loop that further amplifies inflammation and stemness in cancer cells, thereby expanding CSC populations in the tumor.
Toll-like receptors (TLRs) activate NF-κB-mediated inflammatory responses when stimulated by carcinogenic microbes and endogenous molecules released from cells killed during cancer treatment.
NF-κB activation by extrinsic TLR ligands increases stemness in cancer cells.
Moreover, it was recently shown that increased NF-κB activity and inflammatory responses in CSCs may be caused by altered TLR signaling during the enrichment of stemness in cancer cells.
Thus, the activation of TLR signaling by extrinsic and intrinsic factors drives a positive interplay between inflammation and stemness in cancer cells.
American Psychological Association (APA)
Yeh, Da-Wei& Huang, Li-Rung& Chen, Ya-Wen& Huang, Chi-Ying F.& Chuang, Tsung-Hsien. 2016. Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108787
Modern Language Association (MLA)
Yeh, Da-Wei…[et al.]. Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108787
American Medical Association (AMA)
Yeh, Da-Wei& Huang, Li-Rung& Chen, Ya-Wen& Huang, Chi-Ying F.& Chuang, Tsung-Hsien. Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108787