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Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link
Joint Authors
Velázquez-Moctezuma, Javier
Hurtado-Alvarado, Gabriela
Gómez-González, Beatriz
Domínguez-Salazar, Emilio
Pavon, Lenin
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Sleep is a vital phenomenon related to immunomodulation at the central and peripheral level.
Sleep deficient in duration and/or quality is a common problem in the modern society and is considered a risk factor to develop neurodegenerative diseases.
Sleep loss in rodents induces blood-brain barrier disruption and the underlying mechanism is still unknown.
Several reports indicate that sleep loss induces a systemic low-grade inflammation characterized by the release of several molecules, such as cytokines, chemokines, and acute-phase proteins; all of them may promote changes in cellular components of the blood-brain barrier, particularly on brain endothelial cells.
In the present review we discuss the role of inflammatory mediators that increase during sleep loss and their association with general disturbances in peripheral endothelium and epithelium and how those inflammatory mediators may alter the blood-brain barrier.
Finally, this manuscript proposes a hypothetical mechanism by which sleep loss may induce blood-brain barrier disruption, emphasizing the regulatory effect of inflammatory molecules on tight junction proteins.
American Psychological Association (APA)
Hurtado-Alvarado, Gabriela& Domínguez-Salazar, Emilio& Pavon, Lenin& Velázquez-Moctezuma, Javier& Gómez-González, Beatriz. 2016. Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108791
Modern Language Association (MLA)
Hurtado-Alvarado, Gabriela…[et al.]. Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link. Journal of Immunology Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1108791
American Medical Association (AMA)
Hurtado-Alvarado, Gabriela& Domínguez-Salazar, Emilio& Pavon, Lenin& Velázquez-Moctezuma, Javier& Gómez-González, Beatriz. Blood-Brain Barrier Disruption Induced by Chronic Sleep Loss: Low-Grade Inflammation May Be the Link. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108791