How Neutrophil Extracellular Traps Become Visible
Joint Authors
de Buhr, Nicole
von Köckritz-Blickwede, Maren
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neutrophil extracellular traps (NETs) have been identified as a fundamental innate immune defense mechanism against different pathogens.
NETs are characterized as released nuclear DNA associated with histones and granule proteins, which form an extracellular web-like structure that is able to entrap and occasionally kill certain microbes.
Furthermore, NETs have been shown to contribute to several noninfectious disease conditions when released by activated neutrophils during inflammation.
The identification of NETs has mainly been succeeded by various microscopy techniques, for example, immunofluorescence microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM).
Since the last years the development and improvement of new immunofluorescence-based techniques enabled optimized visualization and quantification of NETs.
On the one hand in vitro live-cell imaging led to profound new ideas about the mechanisms involved in the formation and functionality of NETs.
On the other hand different intravital, in vivo, and in situ microscopy techniques led to deeper insights into the role of NET formation during health and disease.
This paper presents an overview of the main used microscopy techniques to visualize NETs and describes their advantages as well as disadvantages.
American Psychological Association (APA)
de Buhr, Nicole& von Köckritz-Blickwede, Maren. 2016. How Neutrophil Extracellular Traps Become Visible. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108793
Modern Language Association (MLA)
de Buhr, Nicole& von Köckritz-Blickwede, Maren. How Neutrophil Extracellular Traps Become Visible. Journal of Immunology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108793
American Medical Association (AMA)
de Buhr, Nicole& von Köckritz-Blickwede, Maren. How Neutrophil Extracellular Traps Become Visible. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108793