Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium
Joint Authors
Lim, Michael
Kim, Eileen S.
Kim, Jennifer E.
Patel, Mira A.
Mangraviti, Antonella
Ruzevick, Jacob
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Immune checkpoints have come to the forefront of cancer therapies as a powerful and promising strategy to stimulate antitumor T cell activity.
Results from recent preclinical and clinical studies demonstrate how checkpoint inhibition can be utilized to prevent tumor immune evasion and both local and systemic immune suppression.
This review encompasses the key immune checkpoints that have been found to play a role in tumorigenesis and, more specifically, gliomagenesis.
The review will provide an overview of the existing preclinical and clinical data, antitumor efficacy, and clinical applications for each checkpoint with respect to GBM, as well as a summary of combination therapies with chemotherapy and radiation.
American Psychological Association (APA)
Kim, Eileen S.& Kim, Jennifer E.& Patel, Mira A.& Mangraviti, Antonella& Ruzevick, Jacob& Lim, Michael. 2016. Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108794
Modern Language Association (MLA)
Kim, Eileen S.…[et al.]. Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108794
American Medical Association (AMA)
Kim, Eileen S.& Kim, Jennifer E.& Patel, Mira A.& Mangraviti, Antonella& Ruzevick, Jacob& Lim, Michael. Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108794