Common Variable Immunodeficiency and Circulating TFH
Joint Authors
Coraglia, Ana
Galassi, Nora
Fernández Romero, Diego S.
Juri, M. Cecilia
Felippo, Marta
Malbrán, Alejandro
Bracco, María M. E. de
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
CD4+ T follicular helper cells ( T F H ) were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II).
T F H lymphocytes were characterized by expression of CXCR5 and PD-1.
T F H were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N).
Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N.
The percentages of Treg and T F H reg were similar in both CVID groups and in N.
T F H responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N.
After submitogenic PHA+IL-2 stimulation, intracellular expression of T F H cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II.
These results suggest that T F H are functional in CVID and highlight the association of increased circulating T F H with AI and GD manifestations.
American Psychological Association (APA)
Coraglia, Ana& Galassi, Nora& Fernández Romero, Diego S.& Juri, M. Cecilia& Felippo, Marta& Malbrán, Alejandro…[et al.]. 2016. Common Variable Immunodeficiency and Circulating TFH. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108802
Modern Language Association (MLA)
Coraglia, Ana…[et al.]. Common Variable Immunodeficiency and Circulating TFH. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108802
American Medical Association (AMA)
Coraglia, Ana& Galassi, Nora& Fernández Romero, Diego S.& Juri, M. Cecilia& Felippo, Marta& Malbrán, Alejandro…[et al.]. Common Variable Immunodeficiency and Circulating TFH. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108802