Neuroprotective Activity of ( - )-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity
Joint Authors
Liu, Jin-Biao
Zhou, Li
Wang, Yi-Zhong
Wang, Xu
Zhou, Yu
Ho, Wen-Zhe
Li, Jie-Liang
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lipopolysaccharide- (LPS-) mediated systemic inflammation plays a critical role in neurodegenerative diseases.
The present study was conducted to evaluate the protective effects of epigallocatechin gallate (EGCG), the major component in green tea, on LPS-mediated inflammation and neurotoxicity.
LPS treatment of macrophages induced expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6).
However, EGCG pretreatment of macrophages significantly inhibited LPS-mediated induction of these cytokines.
In addition, EGCG significantly diminished LPS-induced inflammatory cytokines in the peripheral mononuclear blood cells (PBMCs).
Supernatant from EGCG-pretreated and LPS-activated macrophage cultures was found to be less cytotoxic to neurons than that from non-EGCG-pretreated and LPS-activated macrophage cultures.
Furthermore, EGCG treatment of neurons could inhibit LPS-induced production of reactive oxygen species (ROS).
Thus EGCG represents a potent and useful neuroprotective agent for inflammation-mediated neurological disorders.
American Psychological Association (APA)
Liu, Jin-Biao& Zhou, Li& Wang, Yi-Zhong& Wang, Xu& Zhou, Yu& Ho, Wen-Zhe…[et al.]. 2016. Neuroprotective Activity of ( - )-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108803
Modern Language Association (MLA)
Liu, Jin-Biao…[et al.]. Neuroprotective Activity of ( - )-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108803
American Medical Association (AMA)
Liu, Jin-Biao& Zhou, Li& Wang, Yi-Zhong& Wang, Xu& Zhou, Yu& Ho, Wen-Zhe…[et al.]. Neuroprotective Activity of ( - )-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108803