Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17Treg Balance
Joint Authors
Zou, Qiang
Wang, Yantang
Zhou, Yan
Leng, Xiao
Luo, Shasha
Su, Zhiwei
Luo, Xingyan
Guo, Huijie
Mo, Chunfen
Liu, Yang
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
It is well known that dendritic cells (DCs) play a pivotal role in triggering self-specific responses.
Conversely, tolerogenic DCs (tolDCs), a specialized subset, induce tolerance and negatively regulate autoreactive responses.
Tofacitinib, a Janus kinase inhibitor developed by Pfizer for treatment of rheumatoid arthritis, is probable to be a promising candidate for inducing tolDCs.
The aims of this study were to evaluate the effectiveness of tolDCs induced by tofacitinib in a myelin oligodendrocyte glycoprotein- (MOG-) specific experimental autoimmune encephalomyelitis (EAE) model and to investigate their effects on Th17/Treg balance in the animal model of multiple sclerosis (MS).
Our results revealed that tofacitinib-treated DCs maintained a steady semimature phenotype with a low level of proinflammatory cytokines and costimulatory molecules.
DCs treated by tofacitinib also induced antigen-specific T cells hyporesponsiveness in a concentration-dependent manner.
Upon intravenous injection into EAE mice, MOG pulsed tolDCs significantly dampened disease activity, and adoptive cell therapy (ACT) disturbed Th17/Treg balance with a remarkable decrease of Th1/Th17 cells and an increase in regulatory T cells (Tregs).
Overall, DCs modified by tofacitinib exhibited a typical tolerogenic phenotype, and the antigen-specific tolDCs may represent a new avenue of research for the development of future clinical treatments for MS.
American Psychological Association (APA)
Zhou, Yan& Leng, Xiao& Luo, Shasha& Su, Zhiwei& Luo, Xingyan& Guo, Huijie…[et al.]. 2016. Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17Treg Balance. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108805
Modern Language Association (MLA)
Zhou, Yan…[et al.]. Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17Treg Balance. Journal of Immunology Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108805
American Medical Association (AMA)
Zhou, Yan& Leng, Xiao& Luo, Shasha& Su, Zhiwei& Luo, Xingyan& Guo, Huijie…[et al.]. Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17Treg Balance. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108805