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Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria
Joint Authors
Magnani, Mauro
Schiavano, Giuditta Fiorella
Rinaldi, Laura
Cangiano, Alfonsina Mariarosaria
Dominici, Sabrina
Brandi, Giorgio
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The infection of human macrophages by pathogenic bacteria induces different signaling pathways depending on the type of cellular receptors involved in the microorganism entry and on their mechanism(s) of survival and replication in the host cell.
It was reported that Stat proteins play an important role in this process.
In the present study, we investigate the changes in Stat-1 activation (phosphorylation in p-tyr701) after uptake of two Gram-positive (Listeria monocytogenes and Staphylococcus aureus) and two Gram-negative bacteria (Salmonella typhimurium and Legionella pneumophila) characterized by their varying abilities to enter, survive, and replicate in human macrophages.
Comparing the results obtained with Gram-negative and Gram-positive bacteria, Stat-1 activation in macrophages does not seem to be related to LPS content.
The p-tyr701Stat-1 expression levels were found to be independent of the internalized bacterial number and IFN-γ release.
On the contrary, Jak/Stat-1 pathway activation only occurs when an active infection has been established in the host macrophage, and it is plausible that the differences in the expression levels of p-tyr701Stat-1 could be due to different survival mechanisms or to differences in bacteria life cycles within macrophages.
American Psychological Association (APA)
Schiavano, Giuditta Fiorella& Dominici, Sabrina& Rinaldi, Laura& Cangiano, Alfonsina Mariarosaria& Brandi, Giorgio& Magnani, Mauro. 2016. Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108809
Modern Language Association (MLA)
Schiavano, Giuditta Fiorella…[et al.]. Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108809
American Medical Association (AMA)
Schiavano, Giuditta Fiorella& Dominici, Sabrina& Rinaldi, Laura& Cangiano, Alfonsina Mariarosaria& Brandi, Giorgio& Magnani, Mauro. Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108809