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Group B Streptococcus Induces a Robust IFN-γ Response by CD4+ T Cells in an In Vitro and In Vivo Model
Joint Authors
Clarke, Damian
Letendre, Corinne
Lecours, Marie-Pier
Lemire, Paul
Galbas, Tristan
Thibodeau, Jacques
Segura, Mariela A.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Group B Streptococcus (GBS) serotype III causes life-threatening infections.
Cytokines have emerged as important players for the control of disease, particularly IFN-γ.
Although potential sources of this cytokine have been proposed, no specific cell line has ever been described as a leading contributor.
In this study, CD4+ T cell activation profiles in response to GBS were evaluated through in vivo, ex vivo, and in vitro approaches.
Total splenocytes readily produce a type 1 proinflammatory response by releasing IFN-γ, TNF-α, and IL-6 and actively recruit T cells via chemokines like CXCL9, CXCL10, and CCL3.
Responding CD4+ T cells differentiate into Th1 cells producing large amounts of IFN-γ, TNF-α, and IL-2.
In vitro studies using dendritic cell and CD4+ T cell cocultures infected with wild-type GBS or a nonencapsulated mutant suggested that GBS capsular polysaccharide, one of the major bacterial virulence factors, differentially modulates surface expression of CD69 and IFN-γ production.
Overall, CD4+ T cells are important producers of IFN-γ and might thus influence the course of GBS infection through the expression balance of this cytokine.
American Psychological Association (APA)
Clarke, Damian& Letendre, Corinne& Lecours, Marie-Pier& Lemire, Paul& Galbas, Tristan& Thibodeau, Jacques…[et al.]. 2016. Group B Streptococcus Induces a Robust IFN-γ Response by CD4+ T Cells in an In Vitro and In Vivo Model. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108816
Modern Language Association (MLA)
Clarke, Damian…[et al.]. Group B Streptococcus Induces a Robust IFN-γ Response by CD4+ T Cells in an In Vitro and In Vivo Model. Journal of Immunology Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108816
American Medical Association (AMA)
Clarke, Damian& Letendre, Corinne& Lecours, Marie-Pier& Lemire, Paul& Galbas, Tristan& Thibodeau, Jacques…[et al.]. Group B Streptococcus Induces a Robust IFN-γ Response by CD4+ T Cells in an In Vitro and In Vivo Model. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108816