Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients
Joint Authors
Borska, Lenka
Fiala, Zdenek
Vachatova, Simona
Salavec, Miloslav
Ettler, Karel
Rehacek, Vit
Cermakova, Eva
Malkova, Andrea
Krejsek, Jan
Andrys, Ctirad
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis.
The study is based on the comparison between the group of psoriatic patients (74) and the control group (65).
We found significantly higher BMI ( p < 0.05 ) and diastolic blood pressure ( p < 0.05 ) in the psoriatic patients.
The values of waist circumference and BMI were significantly higher ( p < 0.05 ) in the male patients compared to the men in the control group.
The analysis revealed significantly higher CRP ( p < 0.001 ), Lp-PLA2 ( p < 0.001 ), leptin ( p < 0.01 ), and resistin ( p < 0.01 ) levels in the psoriatic patients.
Significantly higher levels of CRP ( p < 0.01 ), Lp-PLA2 ( p < 0.001 ), leptin ( p < 0.01 ), and resistin ( p < 0.05 ) were found in the patients with MS compared to the controls with MS.
The level of adiponectin was significantly lower ( p < 0.01 ) in the patients with MS.
Finally, we found significantly higher level of Lp-PLA2 ( p < 0.001 ) in the group of patients without MS compared to the controls without MS.
In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis.
The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.
American Psychological Association (APA)
Vachatova, Simona& Andrys, Ctirad& Krejsek, Jan& Salavec, Miloslav& Ettler, Karel& Rehacek, Vit…[et al.]. 2016. Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108820
Modern Language Association (MLA)
Vachatova, Simona…[et al.]. Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108820
American Medical Association (AMA)
Vachatova, Simona& Andrys, Ctirad& Krejsek, Jan& Salavec, Miloslav& Ettler, Karel& Rehacek, Vit…[et al.]. Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108820