CAR T Cell Therapy: A Game Changer in Cancer Treatment
Joint Authors
Vemuri, Mohan
Almåsbak, Hilde
Aarvak, Tanja
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The development of novel targeted therapies with acceptable safety profiles is critical to successful cancer outcomes with better survival rates.
Immunotherapy offers promising opportunities with the potential to induce sustained remissions in patients with refractory disease.
Recent dramatic clinical responses in trials with gene modified T cells expressing chimeric antigen receptors (CARs) in B-cell malignancies have generated great enthusiasm.
This therapy might pave the way for a potential paradigm shift in the way we treat refractory or relapsed cancers.
CARs are genetically engineered receptors that combine the specific binding domains from a tumor targeting antibody with T cell signaling domains to allow specifically targeted antibody redirected T cell activation.
Despite current successes in hematological cancers, we are only in the beginning of exploring the powerful potential of CAR redirected T cells in the control and elimination of resistant, metastatic, or recurrent nonhematological cancers.
This review discusses the application of the CAR T cell therapy, its challenges, and strategies for successful clinical and commercial translation.
American Psychological Association (APA)
Almåsbak, Hilde& Aarvak, Tanja& Vemuri, Mohan. 2016. CAR T Cell Therapy: A Game Changer in Cancer Treatment. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108823
Modern Language Association (MLA)
Almåsbak, Hilde…[et al.]. CAR T Cell Therapy: A Game Changer in Cancer Treatment. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108823
American Medical Association (AMA)
Almåsbak, Hilde& Aarvak, Tanja& Vemuri, Mohan. CAR T Cell Therapy: A Game Changer in Cancer Treatment. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108823