Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease
Joint Authors
Tlaskalova-Hogenova, Helena
Kverka, Miloslav
Coufal, Stepan
Kokesova, Alena
Snajdauf, Jiri
Rygl, Michal
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Necrotizing enterocolitis (NEC) is severe disease of gastrointestinal tract, yet its early symptoms are nonspecific, easily interchangeable with sepsis.
Therefore, reliable biomarkers for early diagnostics are needed in clinical practice.
Here, we analyzed if markers of gut mucosa damage, caspase cleaved cytokeratin 18 (ccCK18) and intestinal fatty acid-binding protein (I-FABP), could be used for differential diagnostics of NEC at early stage of disease.
We collected paired serum (at enrollment and week later) and urine (collected for two days in 6 h intervals) samples from 42 patients with suspected NEC.
These patients were later divided into NEC (n=24), including 13 after gastrointestinal surgery, and sepsis (n=18) groups using standard criteria.
Healthy infants (n=12), without any previous gut surgery, served as controls.
Both biomarkers were measured by a commercial ELISA assay.
There were no statistically significant differences in serum ccCK18 between NEC and sepsis but NEC patients had significantly higher levels of serum and urinary I-FABP than either sepsis patients or healthy infants.
Urinary I-FABP has high sensitivity (81%) and specificity (100%) and can even distinguish NEC from sepsis in patients after surgery.
Urinary I-FABP can be used to distinguish NEC from neonatal sepsis, including postoperative one, better than abdominal X-ray.
American Psychological Association (APA)
Coufal, Stepan& Kokesova, Alena& Tlaskalova-Hogenova, Helena& Snajdauf, Jiri& Rygl, Michal& Kverka, Miloslav. 2016. Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108831
Modern Language Association (MLA)
Coufal, Stepan…[et al.]. Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108831
American Medical Association (AMA)
Coufal, Stepan& Kokesova, Alena& Tlaskalova-Hogenova, Helena& Snajdauf, Jiri& Rygl, Michal& Kverka, Miloslav. Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108831