Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies
Joint Authors
Purushothama, Shobha
Partridge, Michael A.
Elango, Chinnasamy
Lu, Yanmei
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Anti-drug antibodies induced by biologic therapeutics often impact drug pharmacokinetics, pharmacodynamics response, clinical efficacy, and patient safety.
It is critical to assess the immunogenicity risk of potential biotherapeutics in producing neutralizing and nonneutralizing anti-drug antibodies, especially in clinical phases of drug development.
Different assay methodologies have been used to detect all anti-drug antibodies, including ELISA, radioimmunoassay, surface plasmon resonance, and electrochemiluminescence-based technologies.
The most commonly used method is a bridging assay, performed in an ELISA or on the Meso Scale Discovery platform.
In this report, we aim to review the emerging new assay technologies that can complement or address challenges associated with the bridging assay format in screening and confirmation of ADAs.
We also summarize generic anti-drug antibody assays that do not require drug-specific reagents for nonclinical studies.
These generic assays significantly reduce assay development efforts and, therefore, shorten the assay readiness timeline.
American Psychological Association (APA)
Partridge, Michael A.& Purushothama, Shobha& Elango, Chinnasamy& Lu, Yanmei. 2016. Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108839
Modern Language Association (MLA)
Partridge, Michael A.…[et al.]. Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies. Journal of Immunology Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108839
American Medical Association (AMA)
Partridge, Michael A.& Purushothama, Shobha& Elango, Chinnasamy& Lu, Yanmei. Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108839