The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation
Joint Authors
Wan, Wenbin
Kalionis, Bill
Khanabdali, Ramin
Cao, Lan
Xia, Shi-Jin
Tai, Xiantao
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain.
It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients.
Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge.
High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor.
In this review, we present evidence from studies that address the role of HMGB1 in NPP.
First, we review studies aimed at determining the role of HMGB1 in NPP and discuss the possible mechanisms underlying HMGB1-mediated NPP progression where receptors for HMGB1 are involved.
Then we review studies that address HMGB1 as a potential therapeutic target for NPP.
American Psychological Association (APA)
Wan, Wenbin& Cao, Lan& Khanabdali, Ramin& Kalionis, Bill& Tai, Xiantao& Xia, Shi-Jin. 2016. The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108844
Modern Language Association (MLA)
Wan, Wenbin…[et al.]. The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108844
American Medical Association (AMA)
Wan, Wenbin& Cao, Lan& Khanabdali, Ramin& Kalionis, Bill& Tai, Xiantao& Xia, Shi-Jin. The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108844