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Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients
Joint Authors
Draborg, Anette Holck
Jacobsen, Søren
Sandhu, Noreen
Larsen, Nanna
Lisander Larsen, Janni
Houen, Gunnar
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
We analyzed cytokine responses against latent and lytic Epstein-Barr virus (EBV) antigens in systemic lupus erythematosus (SLE) patients and healthy controls (HCs) to obtain an overview of the distinctive immune regulatory response in SLE patients and to expand the previously determined impaired EBV-directed T-cell response.
The concentrations of 14 cytokines (IL2, IL4, IL5, IL6, IL10, IL12, IL17, IL18, IL1β, IFNγ, TNFα, TNFβ, TGFβ, and GM-CSF) were quantified upon stimulation of whole blood with latent state antigen EBNA1, lytic cycle antigen EBV-EA/D, and the superantigen SEB.
To avoid results affected by lack of lymphocytes, we focused on SLE patients with normal levels.
Decreased induction of IL12, IFNγ, IL17, and IL6 upon EBNA1 stimulation and that of IFNγ, IL6, TNFβ, IL1β, and GM-CSF upon EBV-EA/D stimulation were detected in SLE patients compared to HCs.
IFNγ responses, especially, were shown to be reduced.
Induction of several cytokines was furthermore impaired in SLE patients upon SEB stimulation, but no difference was observed in basic levels.
Results substantiate the previously proposed impaired regulation of the immune response against latent and lytic cycle EBV infection in SLE patients without lymphopenia.
Furthermore, results indicate general dysfunction of leukocytes and their cytokine regulations in SLE patients.
American Psychological Association (APA)
Draborg, Anette Holck& Sandhu, Noreen& Larsen, Nanna& Lisander Larsen, Janni& Jacobsen, Søren& Houen, Gunnar. 2016. Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108845
Modern Language Association (MLA)
Draborg, Anette Holck…[et al.]. Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients. Journal of Immunology Research No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1108845
American Medical Association (AMA)
Draborg, Anette Holck& Sandhu, Noreen& Larsen, Nanna& Lisander Larsen, Janni& Jacobsen, Søren& Houen, Gunnar. Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108845