Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils
Joint Authors
Yuan, Ming
Zhu, Ha
Xu, Junfang
Zheng, Yuanyuan
Cao, Xuetao
Liu, Qiuyan
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections.
Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology.
Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice.
In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1.
Furthermore, knocking down CXCL1 expression in 3LL cells significantly hindered tumor growth by inhibiting recruitment of neutrophils from peripheral blood into tumor tissues.
Additionally, tumor-infiltrated neutrophils expressed higher levels of MPO and Fas/FasL, which may be involved in TAN-mediated inhibition of CD4+ and CD8+ T cells.
These results demonstrate that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth.
American Psychological Association (APA)
Yuan, Ming& Zhu, Ha& Xu, Junfang& Zheng, Yuanyuan& Cao, Xuetao& Liu, Qiuyan. 2016. Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108847
Modern Language Association (MLA)
Yuan, Ming…[et al.]. Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108847
American Medical Association (AMA)
Yuan, Ming& Zhu, Ha& Xu, Junfang& Zheng, Yuanyuan& Cao, Xuetao& Liu, Qiuyan. Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108847