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Serum HMGB1 Serves as a Novel Laboratory Indicator Reflecting Disease Activity and Treatment Response in Ankylosing Spondylitis Patients
Joint Authors
Sun, Wei
Wang, Chenqiong
Miao, Ye
Wu, Xuefen
Huang, Yishu
Sun, Mengchen
Zhu, Yingzi
Zheng, Fang
Dong, Lingli
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and inflammatory diseases.
In the current study, we analyzed the association between serum levels of HMGB1 and clinical features of AS patients before and during treatment.
Methods.
Serum HMGB1 was detected in 147 AS patients and 61 healthy controls using ELISA.
We evaluated the association between HMGB1 and extra-articular manifestations as well as disease severity indices.
Among these AS patients, 41 patients received close follow-up at 1, 3, and 6 months after treatment.
This group comprised 25 patients treated with anti-TNF-α biologics and 16 patients receiving oral NSAIDs plus sulfasalazine.
Results.
The serum HMGB1 of AS patients was significantly higher than in healthy controls and positively correlated with BASDAI, BASFI, ASDAS-ESR, ASDAS-CRP, ESR, and CRP, but not with HLA-B27, anterior uveitis, and recurrent diarrhea.
There was no significant difference between patients with radiographic damage of hip joints and those without.
We observed that serum HMGB1 paralleled disease activity after treatment.
Conclusion.
Serum level of HMGB1 is higher in AS patients, and to some extent, HMGB1 can reflect the activity of AS and be used as a laboratory indicator to reflect the therapeutic response.
American Psychological Association (APA)
Wang, Chenqiong& Miao, Ye& Wu, Xuefen& Huang, Yishu& Sun, Mengchen& Zhu, Yingzi…[et al.]. 2016. Serum HMGB1 Serves as a Novel Laboratory Indicator Reflecting Disease Activity and Treatment Response in Ankylosing Spondylitis Patients. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108849
Modern Language Association (MLA)
Wang, Chenqiong…[et al.]. Serum HMGB1 Serves as a Novel Laboratory Indicator Reflecting Disease Activity and Treatment Response in Ankylosing Spondylitis Patients. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108849
American Medical Association (AMA)
Wang, Chenqiong& Miao, Ye& Wu, Xuefen& Huang, Yishu& Sun, Mengchen& Zhu, Yingzi…[et al.]. Serum HMGB1 Serves as a Novel Laboratory Indicator Reflecting Disease Activity and Treatment Response in Ankylosing Spondylitis Patients. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108849