Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model
Joint Authors
Barua, Animesh
Bahr, Janice M.
Bitterman, Pincas
Basu, Sanjib
Abramowicz, Jacques S.
McNeal, Sa’Rah
Edassery, Seby
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ovarian cancer (OVCA) mainly disseminates in the peritoneal cavity.
Immune functions are important to prevent OVCA progression and recurrence.
The mechanism of immunosuppression, a hallmark of tumor progression, is not well understood.
The goal of this study was to determine the immune system’s responses and its suppression during OVCA development and progression in hens.
Frequencies of CD8+ T cells and IgY-containing cells and expression of immunosuppressors including IRG1 and DR6 in OVCA at early and late stages in hens were examined.
Frequencies of stromal but not the intratumoral CD+8 T cells and IgY-containing cells increased significantly ( P < 0.01 ) during OVCA development and progression.
Tumor progression was associated with increased expression of IRG1 and DR6 and decreased infiltration of immune cells into the tumor.
Frequency of stromal but not intratumoral immune cells increases during OVCA development and progression.
Tumor-induced IRG1 and DR6 may prevent immune cells from invading the tumor.
American Psychological Association (APA)
McNeal, Sa’Rah& Bitterman, Pincas& Bahr, Janice M.& Edassery, Seby& Abramowicz, Jacques S.& Basu, Sanjib…[et al.]. 2016. Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108851
Modern Language Association (MLA)
McNeal, Sa’Rah…[et al.]. Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108851
American Medical Association (AMA)
McNeal, Sa’Rah& Bitterman, Pincas& Bahr, Janice M.& Edassery, Seby& Abramowicz, Jacques S.& Basu, Sanjib…[et al.]. Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108851