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Dengue Fever: Causes, Complications, and Vaccine Strategies
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden.
It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes.
Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome.
Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution.
Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes.
Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age.
The impact of its limited application to the public health system needs to be evaluated.
Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals.
In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals.
American Psychological Association (APA)
Khetarpal, Niyati& Khanna, Ira. 2016. Dengue Fever: Causes, Complications, and Vaccine Strategies. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108855
Modern Language Association (MLA)
Khetarpal, Niyati& Khanna, Ira. Dengue Fever: Causes, Complications, and Vaccine Strategies. Journal of Immunology Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108855
American Medical Association (AMA)
Khetarpal, Niyati& Khanna, Ira. Dengue Fever: Causes, Complications, and Vaccine Strategies. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108855