Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers
Joint Authors
Rudge, Marilza Vieira Cunha
Fagundes, Danny Laura Gomes
Calderon, Iracema de Mattos Paranhos
de Queiroz, Adriele Ataides
França, Eduardo Luzía
Honorio-França, Adenilda Cristina
Hara, Cristiane de Castro Pernet
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus.
In the maternal blood from the hyperglycemic groups, the CD16+CD56− NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group.
Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56− and CD16−CD56+.
The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56− cells and, irrespective of region, the proportion of CD16−CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2.
IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group.
IL-17 was higher in maternal and cord blood from the DM-2 group.
The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ.
The GDM group, irrespective of region, showed higher levels of IL-8.
The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ.
The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+.
American Psychological Association (APA)
Hara, Cristiane de Castro Pernet& França, Eduardo Luzía& Fagundes, Danny Laura Gomes& de Queiroz, Adriele Ataides& Rudge, Marilza Vieira Cunha& Honorio-França, Adenilda Cristina…[et al.]. 2016. Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108865
Modern Language Association (MLA)
Hara, Cristiane de Castro Pernet…[et al.]. Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108865
American Medical Association (AMA)
Hara, Cristiane de Castro Pernet& França, Eduardo Luzía& Fagundes, Danny Laura Gomes& de Queiroz, Adriele Ataides& Rudge, Marilza Vieira Cunha& Honorio-França, Adenilda Cristina…[et al.]. Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108865