Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases
Joint Authors
Dianzani, Chiara
Comi, Cristoforo
Clemente, Nausicaa
Raineri, Davide
Boggio, Elena
Favero, Francesco
Soluri, Maria Felicia
Dianzani, Umberto
Chiocchetti, Annalisa
Cappellano, Giuseppe
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Osteopontin (OPN) regulates the immune response at multiple levels.
Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases.
In some cases, the mechanisms of these effects have been described, but many aspects of the OPN function remain elusive.
This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules.
This review describes the OPN structure, isoforms, and functions and its role in regulating the crosstalk between innate and adaptive immunity in autoimmune diseases.
American Psychological Association (APA)
Clemente, Nausicaa& Raineri, Davide& Cappellano, Giuseppe& Boggio, Elena& Favero, Francesco& Soluri, Maria Felicia…[et al.]. 2016. Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108878
Modern Language Association (MLA)
Clemente, Nausicaa…[et al.]. Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases. Journal of Immunology Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1108878
American Medical Association (AMA)
Clemente, Nausicaa& Raineri, Davide& Cappellano, Giuseppe& Boggio, Elena& Favero, Francesco& Soluri, Maria Felicia…[et al.]. Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108878