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Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City
Joint Authors
Campos-Rodriguez, Rafael
Barajas-Castañeda, Luis Miguel
Cortés-Gutiérrez, Evelin
García-Rodríguez, Francisco Mario
Enríquez-Rincón, Fernando
Figueroa-Arredondo, Paula
Lara-Padilla, Eleazar
Castro-Mussot, María Eugenia
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues.
Their role in tumor invasion and metastasis is often discussed.
In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 together with molecules from the fibrinolytic system like uPA, its receptor uPAR, and its inhibitor, PAI-1, were studied by immune-histochemistry to establish a comparison with and without metastasis.
From the (118) primary tumors of Mexican patients with ductal breast cancer studied, 56% were grade II and 69% were size T2; the group with metastatic ganglia included 64 samples (54.3%).
In patients with metastasis the estimated expression of MMP-3 and uPA (resp., 28% and 45%) was higher than that from no metastatic tumors; it means there is higher expression of both markers in metastatic tumors (p<0.05).
At the same time, metastatic tumors showed statistically significant lower signal of PAI-1 (24%) than tumors without metastasis (p<0.05).
We concluded that overexpression of MMP-3 and uPA, altogether with diminished expression of PAI-1 from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.
Nevertheless, additional studies in different populations are necessary to establish a pattern.
American Psychological Association (APA)
Barajas-Castañeda, Luis Miguel& Cortés-Gutiérrez, Evelin& García-Rodríguez, Francisco Mario& Campos-Rodriguez, Rafael& Lara-Padilla, Eleazar& Enríquez-Rincón, Fernando…[et al.]. 2016. Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108899
Modern Language Association (MLA)
Barajas-Castañeda, Luis Miguel…[et al.]. Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City. Journal of Immunology Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108899
American Medical Association (AMA)
Barajas-Castañeda, Luis Miguel& Cortés-Gutiérrez, Evelin& García-Rodríguez, Francisco Mario& Campos-Rodriguez, Rafael& Lara-Padilla, Eleazar& Enríquez-Rincón, Fernando…[et al.]. Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108899