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Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS
Joint Authors
Pittenger, Christopher
Frick, Luciana Romina
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is accumulating evidence that immune dysregulation contributes to the pathophysiology of obsessive-compulsive disorder (OCD), Tourette syndrome, and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).
The mechanistic details of this pathophysiology, however, remain unclear.
Here we focus on one particular component of the immune system: microglia, the brain’s resident immune cells.
The role of microglia in neurodegenerative diseases has been understood in terms of classic, inflammatory activation, which may be both a consequence and a cause of neuronal damage.
In OCD and Tourette syndrome, which are not characterized by frank neural degeneration, the potential role of microglial dysregulation is much less clear.
Here we review the evidence for a neuroinflammatory etiology and microglial dysregulation in OCD, Tourette syndrome, and PANDAS.
We also explore new hypotheses as to the potential contributions of microglial abnormalities to pathophysiology, beyond neuroinflammation, including failures in neuroprotection, lack of support for neuronal survival, and abnormalities in synaptic pruning.
Recent advances in neuroimaging and animal model work are creating new opportunities to elucidate these issues.
American Psychological Association (APA)
Frick, Luciana Romina& Pittenger, Christopher. 2016. Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108902
Modern Language Association (MLA)
Frick, Luciana Romina& Pittenger, Christopher. Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108902
American Medical Association (AMA)
Frick, Luciana Romina& Pittenger, Christopher. Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108902