A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue SyndromeMyalgic Encephalomyelitis and Multiple Sclerosis
Joint Authors
Brenu, E. W.
Ramos, S.
Staines, D.
Broadley, Simon
Nguyen, Thao
Johnston, Samantha
Marshall-Gradisnik, S. M.
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
CD8+ T cells have putative roles in the regulation of adaptive immune responses during infection.
The purpose of this paper is to compare the status of CD8+ T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
Methods.
This preliminary investigation comprised 23 CFS/ME patients, 11 untreated MS patients, and 30 nonfatigued controls.
Whole blood samples were collected from participants, stained with monoclonal antibodies, and analysed on the flow cytometer.
Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+ T cells were divided into naïve, central memory (CM), effector memory CD45RA− (EM), and effector memory CD45RA+ (EMRA) cells.
Results.
Surface expressions of BTLA, CD127, and CD49/CD29 were increased on subsets of CD8+ T cells from MS patients.
In the CFS/ME patients CD127 was significantly decreased on all subsets of CD8+ T cells in comparison to the nonfatigued controls.
PSGL-1 was significantly reduced in the CFS/ME patients in comparison to the nonfatigued controls.
Conclusions.
The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients.
These deficits reported may contribute to the pathogenesis of these diseases.
However, larger sample size is warranted to confirm and support these encouraging preliminary findings.
American Psychological Association (APA)
Brenu, E. W.& Broadley, Simon& Nguyen, Thao& Johnston, Samantha& Ramos, S.& Staines, D.…[et al.]. 2016. A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue SyndromeMyalgic Encephalomyelitis and Multiple Sclerosis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108905
Modern Language Association (MLA)
Brenu, E. W.…[et al.]. A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue SyndromeMyalgic Encephalomyelitis and Multiple Sclerosis. Journal of Immunology Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108905
American Medical Association (AMA)
Brenu, E. W.& Broadley, Simon& Nguyen, Thao& Johnston, Samantha& Ramos, S.& Staines, D.…[et al.]. A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue SyndromeMyalgic Encephalomyelitis and Multiple Sclerosis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108905