Clinical Relevance of HLA Gene Variants in HBV Infection
Joint Authors
Wang, Li
Zou, Zhi-Qiang
Wang, Kai
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Host gene variants may influence the natural history of hepatitis B virus (HBV) infection.
The human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in humans, is one of the most important host factors that are correlated with the clinical course of HBV infection.
Genome-wide association studies (GWASs) have shown that single nucleotide polymorphisms (SNPs) near certain HLA gene loci are strongly associated with not only persistent HBV infection but also spontaneous HBV clearance and seroconversion, disease progression, and the development of liver cirrhosis and HBV-related hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB).
These variations also influence the efficacy of interferon (IFN) and nucleot(s)ide analogue (NA) treatment and response to HBV vaccines.
Meanwhile, discrepant conclusions were reached with different patient cohorts.
It is therefore essential to identify the associations of specific HLA allele variants with disease progression and viral clearance in chronic HBV infection among different ethnic populations.
A better understanding of HLA polymorphism relevance in HBV infection outcome would enable us to elucidate the roles of HLA SNPs in the pathogenesis and clearance of HBV in different areas and ethnic groups, to improve strategies for the prevention and treatment of chronic HBV infection.
American Psychological Association (APA)
Wang, Li& Zou, Zhi-Qiang& Wang, Kai. 2016. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108906
Modern Language Association (MLA)
Wang, Li…[et al.]. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108906
American Medical Association (AMA)
Wang, Li& Zou, Zhi-Qiang& Wang, Kai. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108906