Clinical Relevance of HLA Gene Variants in HBV Infection

Joint Authors

Wang, Li
Zou, Zhi-Qiang
Wang, Kai

Source

Journal of Immunology Research

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-05-08

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Host gene variants may influence the natural history of hepatitis B virus (HBV) infection.

The human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in humans, is one of the most important host factors that are correlated with the clinical course of HBV infection.

Genome-wide association studies (GWASs) have shown that single nucleotide polymorphisms (SNPs) near certain HLA gene loci are strongly associated with not only persistent HBV infection but also spontaneous HBV clearance and seroconversion, disease progression, and the development of liver cirrhosis and HBV-related hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB).

These variations also influence the efficacy of interferon (IFN) and nucleot(s)ide analogue (NA) treatment and response to HBV vaccines.

Meanwhile, discrepant conclusions were reached with different patient cohorts.

It is therefore essential to identify the associations of specific HLA allele variants with disease progression and viral clearance in chronic HBV infection among different ethnic populations.

A better understanding of HLA polymorphism relevance in HBV infection outcome would enable us to elucidate the roles of HLA SNPs in the pathogenesis and clearance of HBV in different areas and ethnic groups, to improve strategies for the prevention and treatment of chronic HBV infection.

American Psychological Association (APA)

Wang, Li& Zou, Zhi-Qiang& Wang, Kai. 2016. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108906

Modern Language Association (MLA)

Wang, Li…[et al.]. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108906

American Medical Association (AMA)

Wang, Li& Zou, Zhi-Qiang& Wang, Kai. Clinical Relevance of HLA Gene Variants in HBV Infection. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108906

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1108906