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Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
Joint Authors
Szigeti, Reka
Kellermayer, Richard
Harris, R. Alan
Shah, Rajesh
Hollister, Emily B.
Tronstad, Rune Rose
Hovdenak, Nils
Versalovic, James
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC).
Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene.
Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
American Psychological Association (APA)
Harris, R. Alan& Shah, Rajesh& Hollister, Emily B.& Tronstad, Rune Rose& Hovdenak, Nils& Szigeti, Reka…[et al.]. 2016. Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108909
Modern Language Association (MLA)
Harris, R. Alan…[et al.]. Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108909
American Medical Association (AMA)
Harris, R. Alan& Shah, Rajesh& Hollister, Emily B.& Tronstad, Rune Rose& Hovdenak, Nils& Szigeti, Reka…[et al.]. Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108909