Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
Joint Authors
Zhou, Keren
Shi, Ligen
Wang, Yan
Zhang, Jianmin
Chen, Sheng
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18.
These cytokines play a critical role in mediating inflammation and innate immunity response.
Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases.
Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome.
In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases.
In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases.
American Psychological Association (APA)
Zhou, Keren& Shi, Ligen& Wang, Yan& Chen, Sheng& Zhang, Jianmin. 2016. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108911
Modern Language Association (MLA)
Zhou, Keren…[et al.]. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders. Journal of Immunology Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108911
American Medical Association (AMA)
Zhou, Keren& Shi, Ligen& Wang, Yan& Chen, Sheng& Zhang, Jianmin. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108911