CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction
Joint Authors
Liu, Bin
Shi, Yuan
Xie, Ke-Liang
Yin, Hai-Fang
Yan, Lu-nan
Lau, Wan-yee
Wang, Guo-Lin
Li, Jing
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic liver allograft dysfunction (CLAD) remains the most common cause of patient morbidity and allograft loss in liver transplant patients.
However, the pathogenesis of CLAD has not been completely elucidated.
By establishing rat CLAD models, in this study, we identified the informative CLAD-associated genes using isobaric tags for relative and absolute quantification (iTRAQ) proteomics analysis and validated these results in recipient rat liver allografts.
CXCL4, CXCR3, EGFR, JAK2, STAT3, and Collagen IV were associated with CLAD pathogenesis.
We validated that CXCL4 is upstream of these informative genes in the isolated hepatic stellate cells (HSC).
Blocking CXCL4 protects against CLAD by reducing liver fibrosis.
Therefore, our results indicated that therapeutic approaches that neutralize CXCL4, a newly identified target of fibrosis, may represent a novel strategy for preventing and treating CLAD after liver transplantation.
American Psychological Association (APA)
Li, Jing& Liu, Bin& Shi, Yuan& Xie, Ke-Liang& Yin, Hai-Fang& Yan, Lu-nan…[et al.]. 2016. CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108914
Modern Language Association (MLA)
Li, Jing…[et al.]. CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108914
American Medical Association (AMA)
Li, Jing& Liu, Bin& Shi, Yuan& Xie, Ke-Liang& Yin, Hai-Fang& Yan, Lu-nan…[et al.]. CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108914