Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome
Joint Authors
Laudanski, Piotr
Lemancewicz, Adam
Zbucka-Kretowska, Monika
Charkiewicz, Karol
Wolczynski, Slawomir
Gościk, Joanna
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Imbalance in the metabolites levels which can potentially be related to certain fetal chromosomal abnormalities can stimulate mother’s immune response to produce autoantibodies directed against proteins.
The aim of the study was to determine the concentration of 9000 autoantibodies in maternal plasma to detect fetal Down syndrome.
Method.
We performed 190 amniocenteses and found 10 patients with confirmed fetal Down syndrome (15th–18th weeks of gestation).
For the purpose of our control we chose 11 women without confirmed chromosomal aberration.
To assess the expression of autoantibodies in the blood plasma, we used a protein microarray, which allows for simultaneous determination of 9000 proteins per sample.
Results.
We revealed 213 statistically significant autoantibodies, whose expression decreased or increased in the study group with fetal Down syndrome.
The second step was to create a classifier of Down syndrome pregnancy, which includes 14 antibodies.
The predictive value of the classifier (specificity and sensitivity) is 100%, classification errors, 0%, cross-validation errors, 0%.
Conclusion.
Our findings suggest that the autoantibodies may play a role in the pathophysiology of Down syndrome pregnancy.
Defining their potential as biochemical markers of Down syndrome pregnancy requires further investigation on larger group of patients.
American Psychological Association (APA)
Charkiewicz, Karol& Zbucka-Kretowska, Monika& Gościk, Joanna& Wolczynski, Slawomir& Lemancewicz, Adam& Laudanski, Piotr. 2016. Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108916
Modern Language Association (MLA)
Charkiewicz, Karol…[et al.]. Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome. Journal of Immunology Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108916
American Medical Association (AMA)
Charkiewicz, Karol& Zbucka-Kretowska, Monika& Gościk, Joanna& Wolczynski, Slawomir& Lemancewicz, Adam& Laudanski, Piotr. Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108916